Yes, some types of chemotherapy can increase cholesterol levels.  Some research has suggested that elevated cholesterol levels, typical of those in a Western-style diet, may accelerate the development of breast tumors and exacerbate their aggressiveness.

Here is a link to a good article that discusses the types of chemo that impact cholesterol levels and ways to improve management of high cholesterol:

http://www.breastcancer.org/treatment/side_effects/inc_cholesterol.jsp

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