Enhance Elimination of Toxic Estrogen Metabolites
Phase 2 detoxification involves methylation and glucuronidation to enhance elimination and inactivate toxic estrogen metabolites. Phase 2 detoxification requires many important enzymatic pathways (sometimes affected by gene mutations) and nutrients such as vitamin B6, B12 folic acid, magnesium, glyceine, as well as a healthy working gastrointestinal tract. Fatty acid balance and mitochondrial function are critical to these processes and can be optimized through nutritional supplements such as omega 3 (DHA/EPA) and co-enzyme Q 10 found in femMED Heart Health.
Decrease Aromatase Activity
After menopause, the ovaries no longer produce estrogen (E2). Instead, post- menopausal estrogen is converted from androgens by an enzyme called, aromatase predominantly in fat tissue. Fat derived “estrone” is a potent stimulator of breast tissue and tightly binds to estrogen receptors. It is strongly associated with breast cancer. Losing weight decreases estrone production. Aromatase activity is inhibited by flax, green tea extract (EGCG), vitamin C, chrysin and flavinoids. Prescription medications such as letrozole also block this enzyme.